World Library  

QR link for Plos One : Subcellular Localization of P44, Volume 7
Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Subcellular Localization of P44, Volume 7

By Nie, Daotai

Click here to view

Book Id: WPLBN0003960413
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Subcellular Localization of P44, Volume 7  
Author: Nie, Daotai
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Nie, D. (n.d.). Plos One : Subcellular Localization of P44, Volume 7. Retrieved from http://community.worldlibrary.in/


Description
Description : The molecular mechanism that controls the proliferation and differentiation of prostate epithelial cells is currently unknown. We previously identified a 44-kDa protein (p44/wdr77) as an androgen receptor-interacting protein that regulates a set of androgen receptor target genes in prostate epithelial cells and prostate cancer. In this study, we found that p44 localizes in the cytoplasm of prostate epithelial cells at the early stage of prostate development when cells are proliferating, and its nuclear translocation is associated with cellular and functional differentiation in adult prostate tissue. We further demonstrated that cytoplasmic p44 protein is essential for proliferation of prostate epithelial cells, whereas nuclear p44 is required for cell differentiation and prostate- specific protein secretion. These studies suggest a novel mechanism by which proliferation and differentiation of prostate epithelial cells are controlled by p44’s location in the cell.

 

Click To View

Additional Books


  • Plos One : a Loss-of-function Screen for... (by )
  • Plos One : Methylated Bsa Mimics Amyloid... (by )
  • Plos One : Inactivation of the Covr, Vol... (by )
  • Plos One : the Impact of Travel Time on ... (by )
  • Plos One : a Udp-x Diphosphatase from St... (by )
  • Plos One : How Explicit and Implicit Tes... (by )
  • Plos One : Label-free Recognition of Dru... (by )
  • Plos One : Enhanced Persistency of Resti... (by )
  • Plos One : Head-to-head Comparison of Hu... (by )
  • Plos One : Innate Immune Detection of Fl... (by )
  • Plos One : Microrna Regulation of Adipos... (by )
  • Plos One : Induction of Apoptosis in Hum... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.